Large serrated polyps: molecular and familial links to a serrated neoplasia predisposition
نویسندگان
چکیده
منابع مشابه
Large serrated polyps: molecular and familial links to a serrated neoplasia predisposition
Background The serrated pathway to colorectal cancer is associated with a CpG-island methylator-phenotype (CIMP) and is distinct of the classical adenoma-to-carcinoma sequence. There is increasing evidence that a subset of hyperplastic polyps (HPs) serves as intermediates in an oncogenic sequence resulting in a CIMP colorectal cancer. This study analyzes molecular changes in large HPs to define...
متن کامل[Serrated polyps and serrated polyposis syndrome].
Serrated polyps of the colorectum are a heterogeneous group of lesions with potential malignant transformation through the «serrated pathway» of carcinogenesis. The discovery of these lesions has been a paradigm shift in the concept of the adenoma-carcinoma sequence, so that up to 30% of tumors develop through this pathway. The main factors associated with an increased risk of malignancy in ser...
متن کاملMolecular characteristics of colorectal serrated polyps and hyperplastic polyps
The serrated neoplasia pathway of colorectal carcinogenesis is characterized by BRAF mutation and aberrant DNA methylation, which have not been reported on Korean patients. The aim of this study was to investigate BRAF mutation and DNA methylation in colorectal serrated polyps and the right colon.Between 2005 and 2013, 146 colon polyps (47 tubular adenomas [TAs], 53 traditional serrated adenoma...
متن کاملSerrated polyps of the colon
Until recently, colonic polyps were traditionally classified as either hyperplastic or adenomatous, and only the latter were believed to have the potential to progress to carcinoma. However, it is now appreciated that a subset of serrated polyps also appear to have malignant potential. Serrated polyps are a heterogeneous group of colon polyps that include hyperplastic polyps, sessile serrated a...
متن کاملExpression of Annexin A10 in Serrated Polyps Predicts the Development of Metachronous Serrated Polyps
OBJECTIVES The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objectiv...
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ژورنال
عنوان ژورنال: Hereditary Cancer in Clinical Practice
سال: 2010
ISSN: 1897-4287
DOI: 10.1186/1897-4287-8-s1-p7